Species differences in zearalenone-reducing activity in subcellular fractions of liver from female domestic animals

Acta Pharmacol Toxicol (Copenh). 1983 Apr;52(4):287-91. doi: 10.1111/j.1600-0773.1983.tb01102.x.


The subcellular distribution of the zearalenone-reducing activity in liver from female pig, goat, sheep, cow and hen was investigated. The distribution patterns for the reduction of zearalenone to alpha- or beta-zearalenol differed between species and was also dependent upon coenzyme. Pig and goat had the greatest ability to form both alpha- and beta-zearalenol in the microsomal fraction independently of coenzyme. Cow and hen formed alpha-zearalenol almost entirely in the microsomal fraction and beta-zearalenol only in the cytosol fraction and only with NADPH as coenzyme. The sheep was distinct from the pig and goat in having the highest alpha-zearalenol forming activity in the cytosol fraction when NADPH was used as coenzyme.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Chickens
  • Female
  • Goats
  • In Vitro Techniques
  • L-Lactate Dehydrogenase / metabolism
  • Liver / metabolism*
  • NADPH-Ferrihemoprotein Reductase / metabolism
  • Oxidation-Reduction
  • Resorcinols / metabolism*
  • Sheep
  • Species Specificity
  • Subcellular Fractions / metabolism*
  • Swine
  • Zearalenone / metabolism*


  • Resorcinols
  • Zearalenone
  • L-Lactate Dehydrogenase
  • NADPH-Ferrihemoprotein Reductase