Comparison of nebulized salbutamol with nebulized ipratropium bromide in acute asthma

Br J Dis Chest. 1983 Apr;77(2):159-63. doi: 10.1016/0007-0971(83)90022-0.


Twelve patients admitted to hospital with an acute attack of bronchial asthma were studied. Six were treated initially with nebulized salbutamol solution by inhalation and 1 hour later by ipratropium bromide given in the same way; the other six were treated first with ipratropium bromide and 1 hour later by salbutamol. Ipratropium bromide was shown to be as effective as salbutamol when used as the initial bronchodilator but salbutamol produced significant further improvement when given 1 hour after ipratropium.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Adult
  • Aerosols
  • Aged
  • Albuterol / therapeutic use*
  • Asthma / drug therapy*
  • Atropine Derivatives / therapeutic use*
  • Female
  • Humans
  • Ipratropium / therapeutic use*
  • Male
  • Middle Aged
  • Respiratory Function Tests


  • Aerosols
  • Atropine Derivatives
  • Ipratropium
  • Albuterol