The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis

Clin Exp Immunol. 1983 Jul;53(1):51-9.


Acute phase reactants, serum immunoglobulins and immune complexes and T cell function were measured in eight patients with active ankylosing spondylitis (AS) before and up to 3 months after three pulses of 1 g methylprednisolone. There was a two stage effect. The first stage was an early anti-inflammatory event with a fall in clinical disease activity mirrored by changes in acute phase reactants particularly prealbumin. The second stage occurred later and was an immunological event with a fall in serum IgA and IgG and a rise in mitogenic response, mixed lymphocyte response and delayed cutaneous hypersensitivity. Most of these changes returned towards pre-treatment levels by 3 months. This study has shown that pulse methylprednisolone has an immediate anti-inflammatory and a prolonged immunological effect in AS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • C-Reactive Protein / metabolism
  • Cell Division
  • Female
  • Humans
  • Hypersensitivity, Delayed
  • Immunoglobulins / analysis
  • Injections, Intravenous
  • Lymphocyte Activation
  • Lymphocyte Culture Test, Mixed
  • Lymphocytes / immunology
  • Male
  • Methylprednisolone / administration & dosage*
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Prealbumin / metabolism
  • Spondylitis, Ankylosing / drug therapy*
  • Spondylitis, Ankylosing / immunology
  • Time Factors


  • Immunoglobulins
  • Prealbumin
  • C-Reactive Protein
  • Methylprednisolone