Abstract
Twenty-seven patients with Felty's syndrome were studied by the colony forming unit in culture (CFU-C) assay for possible immune mechanisms within the bone marrow compartment that could contribute to the neutropenia. Depletion of bone marrow suppressor T cells resulted in normal CFU-C numbers in 7 patients. In 5 patients serum antiprecursor cell activity was detected. Blood monocytes failed to generate colony stimulating factor in 5 patients. Bone marrow-directed immune mechanisms are heterogeneous and could play a role in the pathogenesis of neutropenia in some patients with Felty's syndrome.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adult
-
Aged
-
Agranulocytosis / etiology*
-
Antibody-Dependent Cell Cytotoxicity
-
Antigen-Antibody Complex / analysis
-
Bone Marrow / immunology*
-
Colony-Forming Units Assay
-
Colony-Stimulating Factors / pharmacology
-
Felty Syndrome / blood*
-
Felty Syndrome / physiopathology
-
Female
-
Humans
-
Leukocytes / immunology
-
Male
-
Middle Aged
-
Neutropenia / etiology*
-
Neutropenia / physiopathology
-
T-Lymphocytes, Regulatory / physiopathology
Substances
-
Antigen-Antibody Complex
-
Colony-Stimulating Factors