Abnormal ocular motor control in Huntington's disease

Neurology. 1983 Oct;33(10):1268-75. doi: 10.1212/wnl.33.10.1268.


We studied eye movements in 50 patients with Huntington's disease. Fixation was impaired in 73% of patients; such individuals had difficulty in suppressing saccades toward novel visual stimuli. Impaired initiation of saccades was manifest by increased reaction time (89%) and inability to make a saccade without head movement (89%) or blink (35%). Saccades and quick phases of nystagmus were slowed in 62%. Smooth pursuit was abnormal in 60%, and vergence in 33%. The vestibulo-ocular reflex and the ability to hold eccentric gaze were preserved even late in the disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Eye Movements*
  • Female
  • Fixation, Ocular
  • Head
  • Humans
  • Huntington Disease / physiopathology*
  • Male
  • Middle Aged
  • Motor Activity / physiology
  • Movement