In a series of 388 kidney transplantations performed in 328 patients, aseptic bone necrosis was diagnosed in 27 patients. Forty seven lesions were detected. The femoral head was most often involved (33 cases) followed by the femoral condyle (10 cases), the head of the humerus (3 cases) and the carpal navicular bone (1 case). Sixteen patients had multiple lesions. The first symptoms occurred between the fifth month and the sixth year post-transplantation. With our immunosuppressive protocol, the probability of developing aseptic bone necrosis is 5.2% at one year, 11.3% at two years and 16.3% at six years. The incidence of steroid diabetes is higher in patients with aseptic bone necrosis (26%) than in patients without bone lesions (11%). Conservative treatment was successful in 60% of the cases.