Response of generalized granuloma annulare to high-dose niacinamide

Arch Dermatol. 1983 Oct;119(10):836-9.


A patient with generalized granuloma annulare experienced resolution of her lesions after six months of treatment with 1,500 mg/day of niacinamide. Niacinamide seems to be a reasonably safe drug that, even at relatively high doses, is associated with a low incidence of side effects. The participation of a delayed hypersensitivity reaction in the pathogenesis of granuloma annulare and possible mechanisms involving niacinamide in this type of reaction are discussed.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Granuloma / drug therapy*
  • Granuloma / etiology
  • Granuloma / pathology
  • Humans
  • Hypersensitivity, Delayed / complications
  • Middle Aged
  • Niacinamide / administration & dosage*
  • Skin Diseases / drug therapy*
  • Skin Diseases / etiology
  • Skin Diseases / pathology


  • Niacinamide