Nucleotide sequence of the promoter and amino-terminal coding region of the glutamate dehydrogenase structural gene of Escherichia coli

Gene. 1983 Aug;23(2):199-209. doi: 10.1016/0378-1119(83)90052-5.


A 610-bp DNA fragment carrying the promoter and amino-terminal coding regions of the glutamate dehydrogenase (GDH) structural gene from Escherichia coli has been sequenced. The amino-terminal sequence of the enzyme was also determined to help localize the transcriptional and translational signals for this gene. Three possible promoters and a CRP binding site were identified by concensus criteria. The sequence of 102 amino acids at the amino terminus of the enzyme is compared with the amino acid sequence from other GDH enzymes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cattle
  • Escherichia coli / enzymology
  • Escherichia coli / genetics*
  • Genes
  • Genes, Bacterial*
  • Glutamate Dehydrogenase / biosynthesis
  • Glutamate Dehydrogenase / genetics*
  • Neurospora crassa / enzymology
  • Operon
  • Plasmids
  • Species Specificity
  • Transcription, Genetic


  • Glutamate Dehydrogenase

Associated data

  • GENBANK/J01615
  • GENBANK/K00565