Photoradiation therapy in advanced carcinoma of the trachea and bronchus

Chest. 1984 Jan;85(1):29-33. doi: 10.1378/chest.85.1.29.


Photoradiation therapy is a new technique being investigated for the treatment of solid malignant tumors. In this study, 17 patients with advanced, recurrent, biopsy-proven malignant lesions of the trachea or main-stem bronchus were treated by photoradiation therapy. Patients received hematoporphyrin derivative intravenously three days prior to light therapy. The light was delivered from a fiberoptic fiber attached to the output beam of a dye laser (633 +/- 3 nm). The fiber was passed through the large channel of a bronchoscope (Olympus BF 2T). Of the 17 patients, two had no measurable response to the photoradiation therapy, six had partial necrosis of the tumor, seven patients had a greater than 50 percent reduction in the intraluminal volume of tumor, and two were lost to follow-up. Survival ranged from 5 to 210 days (median survival, 40 days). Complications of the treatment were significant in this group of advanced-stage patients and included excessive secretions, fever, pneumonia, and abscess formation.

MeSH terms

  • Adenocarcinoma / therapy*
  • Bronchial Neoplasms / therapy*
  • Carcinoma, Squamous Cell / therapy*
  • Female
  • Fever / etiology
  • Hematoporphyrin Derivative
  • Hematoporphyrins / therapeutic use*
  • Humans
  • Laser Therapy
  • Male
  • Middle Aged
  • Phototherapy* / adverse effects
  • Pneumonia / etiology
  • Radiation-Sensitizing Agents / therapeutic use*
  • Respiratory Insufficiency / etiology
  • Tracheal Neoplasms / therapy*


  • Hematoporphyrins
  • Radiation-Sensitizing Agents
  • Hematoporphyrin Derivative