The influential T cell in B-cell neoplasms

J Clin Oncol. 1983 Dec;1(12):810-6. doi: 10.1200/JCO.1983.1.12.810.


Investigations of human B-cell malignancies have generally focused on the monoclonal B-cell populations. Until recently there has been little emphasis on the thymus (T) lymphocyte in these disorders. Current studies, however, suggest that quantitative and qualitative disorders of T cells are generally seen both in chronic lymphocytic leukemia and in multiple myeloma. This review will focus on two major concepts. First, it will define the quantitative and functional T-cell abnormalities in B-cell malignancies including evidence suggesting a causal link between the T-cell abnormalities and certain observed disease manifestations in chronic lymphocytic leukemia and multiple myeloma. Secondly, it will review data demonstrating that these T cells may be influenced by in vivo and in vitro manipulations and will outline some of the possible resultant clinical effects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • B-Lymphocytes / immunology
  • Humans
  • Immunity, Cellular
  • Killer Cells, Natural / immunology
  • Leukemia, Lymphoid / immunology*
  • Leukemia, Lymphoid / therapy
  • Leukocyte Count
  • Lymphocyte Activation
  • Multiple Myeloma / immunology*
  • Spleen / radiation effects
  • Splenectomy
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology
  • T-Lymphocytes, Regulatory / immunology
  • Thymosin / pharmacology


  • Thymosin