A genetic study of immunoglobulin E

Am J Hum Genet. 1978 Jan;30(1):46-58.


Path analysis gives evidence of genetic heritability (.425) for serum IgE levels. Complex segregation analysis indicates, in addition to significant polygenic heritability, a major regulatory locus RE, with homozygotes re/re maintaining persistently high levels of IgE. The gene frequency of re is .489, and the displacement is 1.67 standard deviations.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Female
  • Gene Frequency
  • Genes*
  • Humans
  • Hypersensitivity / genetics*
  • Immunoglobulin E / genetics*
  • Male
  • Statistics as Topic


  • Immunoglobulin E