Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Nov 1;129(9):960-5.

Persistent Generalized Lymphadenopathy in Homosexual Men: Clinical, Pathological and Immunologic Characteristics

Free PMC article

Persistent Generalized Lymphadenopathy in Homosexual Men: Clinical, Pathological and Immunologic Characteristics

N J Gilmore et al. Can Med Assoc J. .
Free PMC article

Abstract

Eighteen homosexual men who had had lymphadenopathy in two or more extrainguinal sites for more than 5 months but had no evidence of other illnesses or infections were studied. All had extreme malaise, and 90% had additional symptoms (fever, night sweats, weight loss or gastrointestinal dysfunction). They were compared with 10 healthy homosexual and 10 healthy heterosexual male controls. The mean numbers of circulating T8 (suppressor) lymphocytes were increased equally in the two homosexual groups, but the mean number of T4 (helper) lymphocytes was decreased only in the group with lymphadenopathy. The response to testing for recall anergy was diminished in both homosexual groups but was significantly lower in the group with lymphadenopathy. The serum immunoglobulin and complement concentrations and the numbers of circulating B lymphocytes were normal in each group. Seven of nine lymph node biopsy specimens showed characteristic hyperplasia and confluence of follicles. Thus, idiopathic persistent, generalized lymphadenopathy in homosexual men without opportunistic infections or malignant diseases appears to be a distinct syndrome; it may also be related to the acquired immune deficiency syndrome.

Similar articles

See all similar articles

Cited by 7 articles

See all "Cited by" articles

References

    1. Cancer Res. 1979 Jan;39(1):219-26 - PubMed
    1. Lancet. 1982 Feb 20;1(8269):412-6 - PubMed
    1. Ann Intern Med. 1982 Jun;96(6 Pt 1):693-700 - PubMed
    1. N Engl J Med. 1982 Sep 16;307(12):729-31 - PubMed
    1. Am J Med. 1982 Aug;73(2):171-8 - PubMed

LinkOut - more resources

Feedback