HLA-B27 as a diagnostic screening tool in chronic low back pain

Scand J Rehabil Med. 1984;16(1):27-8.


Forty-five of 52 consecutive patients with chronic low back pain were screened for presence of HLA-B27 antigen one year after they were included in a rehabilitative program. Six (13.3%) were positive and, when re-examined radiographically, 2 had signs of ankylosing spondylitis. The proportion of antigen-positive individuals is similar to that found in a population study of healthy Swedish blood donors, and within the range of other populations of healthy controls. It is concluded that HLA-B27 is of limited diagnostic value as a screening test for ankylosing spondylitis in a patient group with chronic low back pain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Back Pain / etiology*
  • Back Pain / genetics
  • Female
  • HLA Antigens / genetics*
  • HLA-B27 Antigen
  • Humans
  • Male
  • Middle Aged
  • Phenotype
  • Spondylitis, Ankylosing / diagnosis*
  • Spondylitis, Ankylosing / genetics


  • HLA Antigens
  • HLA-B27 Antigen