The role of protein kinase C in cell surface signal transduction and tumour promotion

Nature. 1984 Apr 19-25;308(5961):693-8. doi: 10.1038/308693a0.

Abstract

Protein kinase C has a crucial role in signal transduction for a variety of biologically active substances which activate cellular functions and proliferation. When cells are stimulated, protein kinase C is transiently activated by diacylglycerol which is produced in the membrane during the signal-induced turnover of inositol phospholipids. Tumour-promoting phorbol esters, when intercalated into the cell membrane, may substitute for diacylglycerol and permanently activate protein kinase C. The enzyme probably serves as a receptor for the tumour promoters. Further exploration of the roles of this enzyme may provide clues for understanding the mechanism of cell growth and differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arachidonic Acid
  • Arachidonic Acids / metabolism
  • Calcium / metabolism
  • Carcinogens / metabolism*
  • Cell Membrane / physiology
  • Cell Transformation, Neoplastic*
  • Enzyme Activation
  • Kinetics
  • Membrane Lipids / physiology
  • Phorbol Esters / metabolism
  • Phorbol Esters / toxicity
  • Phospholipids / physiology
  • Protein Kinase C
  • Protein Kinases / metabolism*

Substances

  • Arachidonic Acids
  • Carcinogens
  • Membrane Lipids
  • Phorbol Esters
  • Phospholipids
  • Arachidonic Acid
  • Protein Kinases
  • Protein Kinase C
  • Calcium