Restrictive cardiomyopathy

Annu Rev Med. 1984;35:113-25. doi: 10.1146/


Restrictive cardiomyopathy is a descriptive clinical and hemodynamic syndrome emphasizing the pathophysiologic mechanisms by which myocardial hypertrophy and/or infiltrative processes cause cardiocirculatory morbidity. This diagnosis can be made with precision only after pericardial construction is excluded and myocardial biopsy has identified the restrictive process. Though a variety of rather rare infiltrative pathological entities may be responsible for the restrictive cardiomyopathic picture, most commonly no definitive pathologic diagnosis is established despite extensive hemodynamic and histologic investigation. Nonetheless, a therapeutic trial with a calcium entry blocking agent is warranted.

Publication types

  • Review

MeSH terms

  • Amyloidosis / pathology
  • Cardiomegaly / diagnosis
  • Cardiomegaly / pathology
  • Cardiomegaly / physiopathology
  • Cardiomyopathies / diagnosis*
  • Cardiomyopathies / pathology
  • Cardiomyopathies / physiopathology
  • Diagnosis, Differential
  • Hemodynamics
  • Humans
  • Pericarditis, Constrictive / diagnosis
  • Pericarditis, Constrictive / pathology