Involvement of liver aldehyde oxidase in the reduction of nicotinamide N-oxide

Biochem Biophys Res Commun. 1984 Apr 30;120(2):602-6. doi: 10.1016/0006-291x(84)91297-x.


The present paper describes that mammalian liver aldehyde oxidase is involved in the reduction of nicotinamide N-oxide to nicotinamide. Rabbit liver aldehyde oxidase supplemented with its electron donor exhibited a significant nicotinamide N-oxide reductase activity under anaerobic conditions. Liver cytosols from rabbits, hogs, guinea pigs, hamsters, rats and mice, all of them, similarly exhibited the N-oxide reductase activity in the presence of an electron donor of aldehyde oxidase, but not xanthine oxidase. The cytosolic N-oxide reductase activity was almost completely inhibited by menadione, an inhibitor of aldehyde oxidase.

MeSH terms

  • Aldehyde Oxidase
  • Aldehyde Oxidoreductases / antagonists & inhibitors
  • Aldehyde Oxidoreductases / metabolism*
  • Anaerobiosis
  • Animals
  • Cricetinae
  • Cytosol / enzymology
  • Guinea Pigs
  • Liver / enzymology*
  • Mice
  • Niacinamide / analogs & derivatives*
  • Niacinamide / metabolism
  • Oxidation-Reduction
  • Pyrimidines / metabolism
  • Rabbits
  • Rats
  • Swine
  • Vitamin K / pharmacology


  • Pyrimidines
  • Vitamin K
  • Niacinamide
  • 2-hydroxypyrimidine
  • nicotinamide N-oxide
  • Aldehyde Oxidoreductases
  • Aldehyde Oxidase