Acute interstitial pneumonitis and carbamazepine therapy

Acta Paediatr Scand. 1984 Mar;73(2):285-8. doi: 10.1111/j.1651-2227.1984.tb09948.x.


A 14-year-old girl with skin rash and acute interstitial pneumonitis is presented. She had been taking carbamazepine for two months. Withdrawal of carbamazepine resulted in a prompt improvement of the clinical picture and a normalization of lung function tests. A hypersensitivity reaction to carbamazepine is suggested and the importance of a skin rash as first sign of a generalized reaction is stressed. Lymphocyte-stimulation-tests with carbamazepine were strongly positive in the patient and not in healthy persons nor in patients taking carbamazepine without adverse effects.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Carbamazepine / adverse effects*
  • Drug Eruptions / etiology
  • Drug Hypersensitivity
  • Female
  • Humans
  • Lung Volume Measurements
  • Lymphocyte Activation
  • Pulmonary Fibrosis / chemically induced*


  • Carbamazepine