Teichomycins, new antibiotics from Actinoplanes teichomyceticus nov. sp. IV. Separation and characterization of the components of teichomycin (teicoplanin)

J Antibiot (Tokyo). 1984 Jun;37(6):615-20. doi: 10.7164/antibiotics.37.615.


Teichomycin (teicoplanin) was found to be a mixture of five closely related components of similar polarity, designated T-A2-1, 2, 3, 4 and 5 and of one more polar component, designated T-A3. The separation of the single components was achieved by reverse phase partition chromatography and their physico-chemical and biological properties were compared. The results show that 1) the five major components have the same molecular size of about 1,900; 2) they contain the same ionization function, i.e., a carboxyl group and an amino group which form a zwitterion, and four phenolic groups; 3) they differ in a side aliphatic chain. The component T-A3 is not described.

MeSH terms

  • Actinomycetales / growth & development*
  • Animals
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / toxicity
  • Chemical Phenomena
  • Chemistry
  • Chromatography, High Pressure Liquid
  • Lethal Dose 50
  • Magnetic Resonance Spectroscopy
  • Mice
  • Microbial Sensitivity Tests
  • Spectrophotometry
  • Teicoplanin


  • Anti-Bacterial Agents
  • Teicoplanin