External and biopsy determination of preoperative Tc-99m MDP femoral-head labeling in fracture of the femoral neck: concise communication

J Nucl Med. 1984 Aug;25(8):854-8.


In 30 fresh fractures of the femoral neck, the preoperative femoral-head tracer uptake in Tc-99m MDP scintimetry was compared with the uptake of peroperatively obtained femoral-head biopsies and correlated to intravital bone staining by tetracycline, infused concurrently. Bone uptakes of Tc-99m MDP and tetracycline were shown to correlate well. Total absence of Tc-99m MDP uptake in the femoral-head biopsy corresponded to a scintigraphic uptake ratio of 0.7 (fractured over contralateral head), whereas a normal Tc-99m MDP biopsy uptake corresponded to a ratio of 1.5. This suggests that in Tc-99m MDP scintimetry of a normal hip, less than half of the emission ascribed to the femoral head is derived from the femoral head itself.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Biopsy
  • Diphosphonates*
  • Female
  • Femoral Neck Fractures / diagnosis*
  • Femoral Neck Fractures / diagnostic imaging
  • Femoral Neck Fractures / pathology
  • Femur Head / pathology
  • Femur Head Necrosis / diagnosis*
  • Femur Head Necrosis / diagnostic imaging
  • Femur Head Necrosis / pathology
  • Humans
  • Male
  • Middle Aged
  • Oxytetracycline
  • Radionuclide Imaging
  • Technetium Tc 99m Medronate
  • Technetium*


  • Diphosphonates
  • Technetium
  • Oxytetracycline
  • Technetium Tc 99m Medronate