In vitro activities of norfloxacin and ciprofloxacin against Mycobacterium tuberculosis, M. avium complex, M. chelonei, M. fortuitum, and M. kansasii

Antimicrob Agents Chemother. 1984 Jul;26(1):94-6. doi: 10.1128/AAC.26.1.94.

Abstract

The activities of ciprofloxacin and norfloxacin against 100 mycobacteria isolates were studied in vitro by the 1% standard proportion method. Ciprofloxacin was more active against M. tuberculosis and M. fortuitum with MICs of 1.0 and 0.25 microgram/ml, respectively, against 90% of isolates; norfloxacin had MICs of 8.0 and 2.0 micrograms/ml, respectively, against 90% of isolates.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Antitubercular Agents / pharmacology*
  • Ciprofloxacin
  • Drug Interactions
  • Microbial Sensitivity Tests
  • Mycobacterium avium / drug effects
  • Mycobacterium tuberculosis / drug effects
  • Nalidixic Acid / analogs & derivatives*
  • Nalidixic Acid / pharmacology
  • Norfloxacin
  • Quinolines / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Antitubercular Agents
  • Quinolines
  • Nalidixic Acid
  • Ciprofloxacin
  • Norfloxacin