Muscle disease in progressive systemic sclerosis: diagnostic and therapeutic considerations

Arthritis Rheum. Jan-Feb 1978;21(1):62-71. doi: 10.1002/art.1780210111.

Abstract

Upon careful examination, 23 of 24 patients with progressive systemic sclerosis (PSS) were found to have abnormalities of muscle. Nineteen patients presented a homogenous pattern of muscle abnormalities, which untreated was associated with a stable course ("simple myopathy"). Three patients demonstrated inflammatory muscle disease indistinguishable from polymyositis while a fourth patient developed marked weakness associated with a generalized neuropathic process. Muscle enzymes, electromyogram, and muscle biopsy permitted distinction among the different muscle disorders, a distinction that could have prognostic and therapeutic importance.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Biopsy
  • Creatine Kinase / blood
  • Dermatomyositis / enzymology
  • Dermatomyositis / pathology
  • Electromyography
  • Female
  • Fructose-Bisphosphate Aldolase / blood
  • Humans
  • Male
  • Middle Aged
  • Muscles / pathology
  • Muscular Diseases / complications*
  • Muscular Diseases / enzymology
  • Muscular Diseases / pathology
  • Myositis / enzymology
  • Myositis / pathology
  • Scleroderma, Systemic / complications*
  • Scleroderma, Systemic / enzymology
  • Scleroderma, Systemic / pathology

Substances

  • Creatine Kinase
  • Fructose-Bisphosphate Aldolase