Cholesterol fractions and triglycerides in children and adults with Down's syndrome

Clin Chim Acta. 1984 Oct 15;142(3):307-11. doi: 10.1016/0009-8981(84)90267-5.


In 186 patients with Down's syndrome (age 1-68 yr) total cholesterol and triglycerides were determined, quantitative lipoprotein electrophoresis was performed and cholesterol fractions and beta/alpha-lipoprotein ratios were calculated. A reference group of 51 non-mongoloid mentally handicapped adults living in the same institutions were examined in the same way. Patients' total cholesterol, beta-cholesterol and triglycerides did not differ from the controls. However, alpha-cholesterol was significantly lower and the beta/alpha-lipoprotein ratio significantly higher in patients, findings which are associated in the general population with a high risk for premature atherosclerosis. Interestingly, mortality causes and pathological findings in Down's syndrome show no increased frequency of cardiovascular diseases.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Child
  • Child, Preschool
  • Cholesterol / blood*
  • Down Syndrome / blood*
  • Female
  • Humans
  • Infant
  • Lipoproteins / blood
  • Male
  • Middle Aged
  • Sex Factors
  • Triglycerides / blood*


  • Lipoproteins
  • Triglycerides
  • Cholesterol