The lambda and P22 phage repressors

J Biomol Struct Dyn. 1983 Dec;1(4):1011-22. doi: 10.1080/07391102.1983.10507499.


The lambda cI repressor and the P22 c2 repressor contain two structural domains. In both proteins, the N-terminal domains mediate operator recognition and positive control of transcription, and the C-terminal domains mediate subunit oligomerization and recognition of the recA protein. In some cases, structural, biochemical, and genetic studies implicate particular repressor side chains in these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Bacteriophage lambda / genetics*
  • Binding Sites
  • DNA-Binding Proteins*
  • Models, Molecular
  • Molecular Sequence Data
  • Operator Regions, Genetic
  • Protein Conformation
  • Repressor Proteins* / genetics
  • Salmonella Phages / genetics*
  • Transcription Factors* / genetics
  • Viral Proteins* / genetics
  • Viral Regulatory and Accessory Proteins


  • DNA-Binding Proteins
  • Repressor Proteins
  • Transcription Factors
  • Viral Proteins
  • Viral Regulatory and Accessory Proteins
  • phage repressor proteins