Calmodulin plays a pivotal role in cellular regulation

Science. 1980 Jan 4;207(4426):19-27. doi: 10.1126/science.6243188.

Abstract

The role of calcium ions (Ca2+) in cell function is beginning to be unraveled at the molecular level as a result of recent research on calcium-binding proteins and particularly on calmodulin. These proteins interact reversibly with Ca2+ to form a protein . Ca2+ complex, whose activity is regulated by the cellular flux of Ca2+. Many of the effects of Ca2+ appear to be exerted through calmodulin-regulated enzymes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / metabolism
  • Allosteric Regulation
  • Amino Acid Sequence
  • Animals
  • Biological Evolution
  • Calcium / physiology*
  • Calcium-Binding Proteins / physiology*
  • Calmodulin / physiology*
  • Cell Communication
  • Cyclic AMP / physiology*
  • Enzyme Activation
  • Phospholipases A / metabolism
  • Protein Kinases / metabolism*
  • Receptors, Drug / physiology
  • Structure-Activity Relationship
  • Troponin / physiology

Substances

  • Calcium-Binding Proteins
  • Calmodulin
  • Receptors, Drug
  • Troponin
  • Cyclic AMP
  • Protein Kinases
  • Phospholipases A
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Calcium