Malignant fibrous histiocytoma: a retrospective study of 167 cases

Cancer. 1980 Jan 1;45(1):167-78. doi: 10.1002/1097-0142(19800101)45:1<167::aid-cncr2820450127>;2-8.


A retrospective study of 167 patients with soft-tissue malignant fibrous histiocytoma of the trunk, extremities, and retroperitoneal region revealed twice as many deeply situated tumors as superficial tumors. Malignant fibrous histiocytoma may be subclassified into fibrous, giant-cell, myxoid, and inflammatory variants. The fibrous variant accounted for two-thirds of the lesions. The prognosis is no different among the histologic subtypes. The depth of the tumor significantly affects survival, and three important groups were identified: superficial tumors, superficial tumors that recur in deep locations, and deeply situated tumors. The group with superficial tumors that subsequently did not recur in deep locations had a significantly better 4-year survival rate than did the other two groups (65% versus 34% and 40%, respectively). Patients with distally located tumors had a better 5-year survival rate than did patients with proximally located tumors (73% versus 28%). Local recurrence was found in 51% of patients who had a "complete" excision. Patients with superficial tumors had a higher local recurrence rate (71%) than did those with deep tumors (41%). Few patients with retroperitoneal tumors were long-term survivors; the 5-year survival rate was 14%.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Extremities
  • Female
  • Histiocytoma, Benign Fibrous / pathology*
  • Histiocytoma, Benign Fibrous / secondary
  • Histiocytoma, Benign Fibrous / therapy
  • Humans
  • Lung Neoplasms / secondary
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / therapy
  • Prognosis
  • Retroperitoneal Neoplasms / pathology
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / therapy