Tachyphylaxis to inhaled isoproterenol and the effect of methylprednisolone in dogs

J Allergy Clin Immunol. 1980 Feb;65(2):105-9. doi: 10.1016/0091-6749(80)90193-1.


Acute tachyphylaxis can be induced to inhaled isoproterenol (ISO) in anesthetized, closed-chested mongrel dogs. The responsiveness to ISO measured as the percent reduction in methacholine-induced bronchoconstriction was decreased significantly (p less than 0.01) after a 1-hr period of repeated ISO inhalations (ISO-loading). Intravenous administration of methylprednisolone (1 mg/kg) reversed the decrease in responsiveness to ISO.

MeSH terms

  • Animals
  • Dogs
  • Dose-Response Relationship, Drug
  • Humans
  • Isoproterenol / adverse effects*
  • Methacholine Compounds / pharmacology
  • Methylprednisolone / therapeutic use*
  • Norepinephrine / pharmacology
  • Rats
  • Receptors, Adrenergic, alpha / immunology
  • Tachyphylaxis*


  • Methacholine Compounds
  • Receptors, Adrenergic, alpha
  • Isoproterenol
  • Norepinephrine
  • Methylprednisolone