Postsynaptic transmission block can cause terminal sprouting of a motor nerve

Science. 1980 Feb 8;207(4431):649-51. doi: 10.1126/science.6243417.

Abstract

Sprouting of mouse soleus motor nerve terminals can be evoked by daily intramuscular injections of purified alpha-bungarotoxin. This finding supports the hypothesis that an important stimulus to terminal sprouting in partial denervation and presynaptic nerve blockade is a product of inactive muscle fibers.

MeSH terms

  • Animals
  • Botulinum Toxins / pharmacology
  • Bungarotoxins / pharmacology*
  • Female
  • Mice
  • Motor Endplate / drug effects
  • Motor Neurons / growth & development*
  • Muscles / innervation
  • Neuromuscular Junction / physiology*
  • Receptors, Cholinergic / drug effects
  • Synaptic Transmission / drug effects*

Substances

  • Bungarotoxins
  • Receptors, Cholinergic
  • Botulinum Toxins