Cellular site of opiate dependence

Nature. 1980 Feb 14;283(5748):625-9. doi: 10.1038/283625a0.


Experiments on whole animals, guinea pig isolated ileum, individual neurones in situ and cultured neuroblastoma--glioma hybrid cells indicate that opiate dependence and associated tolerance develop within neurones bearing specific opiate receptors (opiate-sensitive neurones). The essential change appears to be an hypertrophy of the cyclic AMP system, in response to inhibition by opiate of a neuronal adenylate cyclase.

MeSH terms

  • Action Potentials
  • Animals
  • Brain / drug effects*
  • Cells, Cultured
  • Cyclic AMP / metabolism
  • Drug Tolerance
  • Guinea Pigs
  • Humans
  • Hybrid Cells / drug effects
  • Ileum / innervation
  • In Vitro Techniques
  • Myenteric Plexus / drug effects*
  • Naloxone / pharmacology
  • Opioid-Related Disorders*
  • Receptors, Opioid / drug effects*
  • Substance Withdrawal Syndrome / physiopathology


  • Receptors, Opioid
  • Naloxone
  • Cyclic AMP