Sarcoid polyneuropathy: a histologically proved case

Ann Neurol. 1980 Feb;7(2):178-81. doi: 10.1002/ana.410070213.


A 58-year-old patient had subacute polyneuropathy. Electrophysiological studies showed inexcitability of the distal portion of the peroneal and posterior tibial nerves and minimal reduction in amplitude of the muscle potential with minimal slowing in motor nerve conduction velocity. The sural nerve biopsy showed multiple sarcoid granulomas in the epineurial and perineurial spaces, periangiitis and panangiitis, and axonal degeneration. Remarkable clinical improvement followed corticosteroid treatment.

Publication types

  • Case Reports

MeSH terms

  • Electromyography
  • Female
  • Humans
  • Middle Aged
  • Muscles / physiopathology
  • Neural Conduction
  • Peripheral Nerves / pathology*
  • Peripheral Nerves / physiopathology
  • Peripheral Nervous System Diseases / pathology*
  • Peripheral Nervous System Diseases / physiopathology
  • Sarcoidosis / pathology*
  • Sarcoidosis / physiopathology
  • Vasa Nervorum / pathology
  • Vasculitis / pathology