A mechanism for RNA splicing

Proc Natl Acad Sci U S A. 1980 Apr;77(4):1877-9. doi: 10.1073/pnas.77.4.1877.

Abstract

The most abundant of the stable small nuclear RNAs of eukaryotic cells, U-1 small nuclear RNA, is exactly complementary to the consensus sequences at RNA splice sites. We propose that this RNA is the recognition component of the nuclear RNA splicing enzyme and forms base pairs with both ends of an intron so as to align them for cutting and splicing.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Neoplasm / genetics
  • Base Sequence
  • Cell Nucleus / metabolism
  • Genes
  • Insulin / genetics
  • Nucleic Acid Conformation
  • Nucleic Acid Precursors / metabolism*
  • RNA, Heterogeneous Nuclear / metabolism*
  • RNA, Messenger / metabolism*
  • Rats
  • Simian virus 40 / genetics

Substances

  • Antigens, Neoplasm
  • Insulin
  • Nucleic Acid Precursors
  • RNA, Heterogeneous Nuclear
  • RNA, Messenger