Abstract
The effect of ketamine on sympathetic ganglion transmission has been studied using the guineapig isolated hypogastric nerve-vas deferens preparation. Ketamine produced a dose-dependent depression in the response to preganglionic stimulation (IC50 2.05 X 10--4 mol litre--1). No change in the response to postganglionic stimulation was recorded. The anti-cholinergic activity of ketamine was confirmed using the frog isolated rectus abdominis.
MeSH terms
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Abdominal Muscles / drug effects
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Animals
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Anura
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Carbachol / pharmacology
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Dose-Response Relationship, Drug
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Ganglia, Sympathetic / drug effects*
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Ganglia, Sympathetic / physiology
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Guinea Pigs
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Hexamethonium Compounds / pharmacology
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In Vitro Techniques
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Ketamine / pharmacology*
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Male
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Muscle Contraction / drug effects
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Potassium Chloride / pharmacology
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Rana temporaria
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Synaptic Transmission / drug effects*
Substances
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Hexamethonium Compounds
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Potassium Chloride
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Ketamine
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Carbachol