Beta 2-adrenoceptors mediate the stimulating effect of adrenaline on active electrogenic Na-K-transport in rat soleus muscle

Br J Pharmacol. 1980 Apr;68(4):749-55. doi: 10.1111/j.1476-5381.1980.tb10868.x.


The relative role of beta 1- and beta 2-adrenoceptors in mediating the stimulating effect of adrenaline on active electrogenic Na-K-transport has been assessed in experiments on rat soleus muscles in vitro and in vivo. 2 In the rat isolated soleus muscle, adrenaline (10(-6) M) increases the resting membrane potential (EM) by 5.8 mV and stimulates 22Na-efflux and ouabain-suppressible 42K-uptake by 91 and 94%, respectively. 3 All of these effects are completely blocked by propranolol (10(-5) M), whereas the beta 1-selective adrenoceptor antagonist, metoprolol, was found to be at least 50 times less potent. 4 The beta 2-adrenoceptor agonist, salbutamol, was at least 100 times as potent as H133/22 (a beta 1-selective agonist) in stimulating 22Na-efflux and 42K-influx. 5 In experiments performed under pentobarbitone anaesthesia, the intravenous injection of adrenaline (5 microgram) or salbutamol (0.5 to 50 microgram) led to a rapid and marked increase in the EM of the exposed soleus muscle. This hyperpolarizing effect could not be accounted for by the concomitant, relatively modest change in extracellular K.

MeSH terms

  • Albuterol / pharmacology
  • Animals
  • Biological Transport, Active / drug effects
  • Epinephrine / pharmacology*
  • Female
  • In Vitro Techniques
  • Male
  • Membrane Potentials / drug effects
  • Muscles / drug effects
  • Muscles / metabolism*
  • Potassium / metabolism*
  • Rats
  • Receptors, Adrenergic / physiology*
  • Receptors, Adrenergic, beta / physiology*
  • Sodium / metabolism*
  • Time Factors


  • Receptors, Adrenergic
  • Receptors, Adrenergic, beta
  • Sodium
  • Albuterol
  • Potassium
  • Epinephrine