Plasma protein binding of d-propoxyphene in normal subjects and anephric patients

J Clin Pharmacol. Feb-Mar 1978;18(2-3):106-9. doi: 10.1002/j.1552-4604.1978.tb02429.x.

Abstract

The free fraction of d-propoxyphene in the plasma of normal subjects is 0.24 +/- 0.02 (mean +/- S.D.) and is not concentration dependent in the usual therapeutic and toxic conentration range. Renal failure and relatively high concentrations of d-norpropoxyphene, the major metabolite of d-propoxyphene, have no significant effect on the plasma protein binding of d-propoxyphene.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Blood Proteins / metabolism*
  • Dextropropoxyphene / analogs & derivatives
  • Dextropropoxyphene / blood*
  • Dextropropoxyphene / pharmacology
  • Female
  • Humans
  • In Vitro Techniques
  • Kidney / physiology*
  • Kidney Failure, Chronic / blood*
  • Male
  • Nephrectomy
  • Protein Binding / drug effects

Substances

  • Blood Proteins
  • Dextropropoxyphene