Microneutalization of cytomegalovirus

J Infect Dis. 1980 Jul;142(1):102-5. doi: 10.1093/infdis/142.1.102.


A simple microneutralization test for cytomegalovirus (CMV) is presented. Using a laboratory adapted stock virus, definite results were obtained after 10 days. All patients with primary CMV infection showed an antibody rise and/or seroconversion; however, neutralizing antibody appeared only seven weeks after the onset of clinical symptoms. In control patients without evidence of recent primary infection, there was a complete concordance of the presence of complement-fixing and neutralizing antibodies.

MeSH terms

  • Animals
  • Antibodies, Viral / analysis
  • Complement System Proteins
  • Cytomegalovirus / immunology*
  • Cytopathogenic Effect, Viral
  • Guinea Pigs
  • Humans
  • Neutralization Tests


  • Antibodies, Viral
  • Complement System Proteins