Regional assignment of catalase (CAT) gene to band 11p13. Association with the aniridia-Wilms' tumor-Gonadoblastoma (WAGR) complex

Ann Genet. 1980;23(3):165-8.

Abstract

A gene dosage effect for catalase (CAT) was investigated in three individuals : one with 11p13 deletion, aniridia, ambiguous genitalla, and gonadoblastoma ; one trisomic for 11p with the exception of 11p13; and one trisomic for 11p13. Results were compatible with the assignment of CAT to 11p13 and its linkage with the aniridia-gonadoblastoma or Wilms' tumor complex (WAGR).

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Catalase / blood
  • Catalase / genetics*
  • Child
  • Chromosome Mapping
  • Chromosomes, Human, 6-12 and X*
  • Clinical Enzyme Tests
  • Dysgerminoma / genetics*
  • Female
  • Humans
  • Infant
  • Iris / abnormalities*
  • Kidney Neoplasms / genetics
  • Male
  • Neoplasms, Multiple Primary / genetics
  • Wilms Tumor / genetics*

Substances

  • Catalase