Leaky +1 and -1 frameshift mutations at the same site in a yeast mitochondrial gene

Nature. 1980 Nov 6;288(5786):60-3. doi: 10.1038/288060a0.

Abstract

Two mutations in a mitochondrial structural gene, which cause leaky premature polypeptide chain termination and leaky growth, are +1 and -1 frameshifts in the same run of five T residues. The partial restoration of reading frame is probably due to ribosomal frameshifting at this site, and may be promoted by the unique structure of the yeast mitochondrial t RNAPhe.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Mitochondrial / genetics*
  • Electron Transport Complex IV / genetics
  • Genes
  • Mutation
  • Phenotype
  • Protein Biosynthesis
  • RNA, Transfer / genetics
  • Ribosomes / metabolism
  • Saccharomyces cerevisiae / genetics*

Substances

  • DNA, Mitochondrial
  • RNA, Transfer
  • Electron Transport Complex IV