The presence of nuclear and mitochondrial uracil-DNA glycosylase in extracts of human KB cells

Nucleic Acids Res. 1980 Feb 25;8(4):875-88.


Extracts of human KB cells contain detectable uracil-DNA glycosylase activity. The majority of the activity is located within the nuclear fraction, however we present evidence for the presence of identifiable uracil-DNA glycosylase activity associated with the mitochondrial fraction of these cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Nucleus / enzymology*
  • Cells, Cultured
  • DNA Glycosylases*
  • Electron Transport Complex IV / metabolism
  • Humans
  • Mitochondria / enzymology*
  • N-Glycosyl Hydrolases / antagonists & inhibitors
  • N-Glycosyl Hydrolases / metabolism*
  • Uracil-DNA Glycosidase


  • Electron Transport Complex IV
  • DNA Glycosylases
  • N-Glycosyl Hydrolases
  • Uracil-DNA Glycosidase