Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways

Science. 1980 Dec 12;210(4475):1252-3. doi: 10.1126/science.6254154.


Vasoactive intestinal peptide, a smooth-muscle relaxant neuropeptide with neurotransmitter properties, was relaxed during electrical field stimulation of guinea pig trachea. The amount released correlated with the degree of relaxation, and the release was blocked by tetrodotoxin. Prior incubation of the trachea with antiserum to vasoactive intestinal peptide reduced the relaxation. Thus vasoactive intestinal peptide may mediate the nonadrenergic relaxation of tracheal smooth muscle.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenergic Fibers / physiology*
  • Animals
  • Antigen-Antibody Reactions
  • Electric Stimulation
  • Female
  • Gastrointestinal Hormones / physiology*
  • Humans
  • Mice
  • Muscle Contraction*
  • Muscle Relaxation*
  • Muscle, Smooth / drug effects
  • Neural Inhibition
  • Synaptic Transmission
  • Tetrodotoxin / pharmacology
  • Trachea / innervation*
  • Vasoactive Intestinal Peptide / immunology
  • Vasoactive Intestinal Peptide / physiology*


  • Gastrointestinal Hormones
  • Vasoactive Intestinal Peptide
  • Tetrodotoxin