C-6 glioma growth in rats: suppression with a beta-adrenergic agonist and a phosphodiesterase inhibitor

Ann Neurol. 1980 Oct;8(4):447-9. doi: 10.1002/ana.410080421.


Rat C-6 glioma possesses a beta-adrenergic receptor which, when activated, raises intracellular levels of cyclic adenosine monophosphate (cAMP) in cultured C-6 glioma cells. The present study shows that growth of C-6 glioma is suppressed in rats treated with the beta-adrenergic agonist isoproterenol. Addition of papaverine, a cAMP phosphodiesterase inhibitor, to the treatment schedule augments this effect. Pharmacological agents that elevate intracellular cAMP levels may retard the growth of neural tumors in vivo.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / metabolism
  • Cell Line
  • Cyclic AMP / metabolism
  • Drug Therapy, Combination
  • Glioma / drug therapy*
  • Glioma / metabolism
  • Humans
  • Isoproterenol / administration & dosage*
  • Neoplasm Transplantation
  • Neoplasms, Experimental
  • Papaverine / administration & dosage*
  • Rats


  • Papaverine
  • Cyclic AMP
  • Isoproterenol