7,N,N-Trimethyltryptamine: a selective inhibitor of synaptosomal serotonin uptake

Res Commun Chem Pathol Pharmacol. 1978 Jan;19(1):161-4.

Abstract

7,N,N-Trimethyltryptamine (TMT) was synthesized and evaluated as an inhibitor of synaptosomal biogenic amine uptake in rat forebrain homogenates. In addition to inhibiting 3H-serotonin uptake (IC50 = 0.4 micrometer), TMT appears to be quite selective and is much less potent in blocking either 3H-norepinephrine or 3H-dopamine uptake (IC50 = 180 micrometer and 61 micrometer, respectively).

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Avoidance Learning / drug effects
  • Brain / metabolism
  • Brain / ultrastructure
  • Depression, Chemical
  • In Vitro Techniques
  • Male
  • Rats
  • Serotonin / metabolism*
  • Synaptosomes / drug effects
  • Synaptosomes / metabolism*
  • Tryptamines / pharmacology*

Substances

  • Tryptamines
  • Serotonin