Abstract
Prostaglandins (PGE1) and dibutyryl cyclic AMP (dBc AMP) induce similar morphological changes in astrocytes obtained in primary cultures. PGE1 and dBc AMP increased 2 enzymes of GABA and glutamate metabolism, GABA-T and AAT, but did not modify GDH and GLN-S. Prostaglandins probably affect the cAMP content of glial cells and act in the same way as dBc AMP on glial cell differentiation.
MeSH terms
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4-Aminobutyrate Transaminase / metabolism*
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Adult
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Animals
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Aspartate Aminotransferases / metabolism*
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Astrocytes / cytology
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Astrocytes / drug effects*
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Astrocytes / enzymology
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Bucladesine / pharmacology*
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Cells, Cultured
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Humans
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Prostaglandins E / pharmacology*
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Transaminases / metabolism*
Substances
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Prostaglandins E
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Bucladesine
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Transaminases
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Aspartate Aminotransferases
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4-Aminobutyrate Transaminase