Abstract
1-(2-Deoxy-beta-D-ribofuranosyl)-5-(methylmercapto)-2-pyrimidinone (1b) was synthesized via modification of the silyl method. 1b inhibits the Herpes simplex virus type 1 (98%) and type 2 (97%) at a concentration which is nontoxic to human HeLa cells. The compound shows 50 times greater binding affinity (lower Ki) to the virus-specific thymidine kinase than to the thymidine kinase of uninfected HeLa cells.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / metabolism
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Chemical Phenomena
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Chemistry
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Humans
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Simplexvirus / drug effects
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Thionucleosides / chemical synthesis*
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Thionucleosides / pharmacology
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Thymidine Kinase / metabolism
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Viral Plaque Assay
Substances
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Antiviral Agents
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Thionucleosides
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1-(2-deoxy-beta-D-ribofuranosyl)-5-(methylmercapto)-2-pyrimidinone
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Thymidine Kinase