In vivo sequence requirements of the SV40 early promotor region

Nature. 1981 Mar 26;290(5804):304-10. doi: 10.1038/290304a0.

Abstract

To investigate the sequences necessary for proper initiation of transcription of SV40 early genes, we have constructed several deletion mutants in the promoter region. The TATA box region is apparently involved in fixing initiation precisely within a narrow area, but is dispensable for gene expression, while the sequences located more than 150 base pairs upstream are indispensable.

MeSH terms

  • Antigens, Neoplasm / genetics*
  • Antigens, Viral / genetics*
  • Antigens, Viral, Tumor
  • Base Sequence
  • DNA, Viral / genetics
  • Gene Expression Regulation
  • Mutation
  • Operon*
  • Simian virus 40*
  • Transcription, Genetic*

Substances

  • Antigens, Neoplasm
  • Antigens, Viral
  • Antigens, Viral, Tumor
  • DNA, Viral

Associated data

  • GENBANK/J02400
  • GENBANK/J02402
  • GENBANK/J02403
  • GENBANK/J02406
  • GENBANK/J02407
  • GENBANK/J02408
  • GENBANK/J02409
  • GENBANK/J02410
  • GENBANK/V01380