A comparison of drug-metabolizing capability in isolated viable rat hepatocytes and renal tubule fragments

Xenobiotica. 1978 Feb;8(2):113-20. doi: 10.3109/00498257809060390.

Abstract

1. The metabolism of a number of xenobiotics has been investigated in isolated viable rat hepatocytes and kidney tubule fragments in suspension. 2. The level of Phase I metabolism was very low in the kidney cells although such cells possess appreciable Phase II metabolic capacity. 3. These findings are discussed in relation to the physiological role of cytochrome P-450 and the conjugating enzymes, and the value of intact cells systems in assessing inter-organ differences in xenobiotic metabolism.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Benzoates / metabolism
  • Benzopyrenes / metabolism
  • Biphenyl Compounds / metabolism
  • Coumarins / metabolism
  • Hymecromone / metabolism
  • In Vitro Techniques
  • Kidney Tubules / metabolism*
  • Liver / cytology
  • Liver / metabolism*
  • Male
  • Pharmaceutical Preparations / metabolism*
  • Rats

Substances

  • Benzoates
  • Benzopyrenes
  • Biphenyl Compounds
  • Coumarins
  • Pharmaceutical Preparations
  • Hymecromone