Increased resting and evoked release of transmitter following repetitive electrical tetanization in hippocampus: a biochemical correlate to long-lasting synaptic potentiation

Brain Res. 1981 Mar 16;208(2):436-41. doi: 10.1016/0006-8993(81)90573-4.


In vitro stimulation of two axonal branches from hippocampal CA3 pyramids, the CA1 afferent Schaffer collaterals and the CA3 efferents to septum through fimbria, released D-[3H]aspartate as a measure for endogenous L-glutamate. Following bursts of repetitive electrical stimuli to the Schaffer collaterals, a long-lasting and significantly increased resting efflux, as well as an increased stimulus evoked release of D-aspartate, appeared. No such persistent increase in D-aspartate efflux was recorded from the septal terminals. We propose that increased transmitter liberation may account for long-term synaptic potentiation in hippocampus.

MeSH terms

  • Animals
  • Aspartic Acid / metabolism*
  • Calcium / pharmacology
  • Culture Techniques
  • Electric Stimulation
  • Evoked Potentials
  • Guinea Pigs
  • Hippocampus / physiology*
  • Nerve Fibers / physiology
  • Neural Pathways / physiology
  • Neurons / physiology
  • Septum Pellucidum / physiology
  • Synapses / physiology*
  • Synaptic Transmission*


  • Aspartic Acid
  • Calcium