Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

Nature. 1981 Apr 9;290(5806):475-80. doi: 10.1038/290475a0.


Analyses of DNA and RNA from avian leukosis virus (ALV)-induced lymphomas have provided strong evidence that, in most tumours, ALV induces neoplastic disease by activating the c-myc gene, the cellular counterpart of the transforming gene of MC29 virus. The data indicate that, as a rare event, the ALV provirus integrates adjacent to the c-myc gene and that transcription, initiating from a viral promoter, causes enhanced expression of c-myc, leading to neoplastic transformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Avian Leukosis Virus / genetics*
  • Base Sequence
  • Cell Transformation, Viral*
  • DNA, Viral / genetics*
  • Genes
  • Genetic Linkage
  • Lymphoma / genetics*
  • Operon*
  • RNA, Neoplasm / genetics
  • RNA, Viral / genetics
  • Transcription, Genetic


  • DNA, Viral
  • RNA, Neoplasm
  • RNA, Viral