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, 33 (3), 323-51

Relationship Between Presynaptic Calcium Current and Postsynaptic Potential in Squid Giant Synapse

Relationship Between Presynaptic Calcium Current and Postsynaptic Potential in Squid Giant Synapse

R Llinás et al. Biophys J.

Abstract

The relationship between calcium current and transmitter release was studied in squid giant synapse. It was found that the voltage-dependent calcium current triggers the release of synaptic transmitter in direct proportion to its magnitude and duration. Transmitter release occurs with a delay of approximately 200 mus after the influx of calcium. A model is presented which describes these relations formally.

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