Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse

Biophys J. 1981 Mar;33(3):323-51. doi: 10.1016/S0006-3495(81)84899-0.


The relationship between calcium current and transmitter release was studied in squid giant synapse. It was found that the voltage-dependent calcium current triggers the release of synaptic transmitter in direct proportion to its magnitude and duration. Transmitter release occurs with a delay of approximately 200 mus after the influx of calcium. A model is presented which describes these relations formally.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Calcium / pharmacology*
  • Decapodiformes
  • Electric Conductivity
  • Mathematics
  • Synapses / drug effects
  • Synapses / physiology*
  • Synaptic Transmission / drug effects


  • Calcium