Relation of arginine-lysine antagonism to herpes simplex growth in tissue culture

Chemotherapy. 1981;27(3):209-13. doi: 10.1159/000237979.


In the studies conducted, arginine deficiency suppressed herpes simplex virus replication in tissue culture. Lysine, an analog of arginine, as an antimetabolite, antagonized the viral growth-promoting action of arginine. The in vitro data may be the basis for the observation that patients prone to herpetic lesions and other related viral infections, particularly during periods of stress, should abstain from arginine excess and may also require supplemental lysine in their diet.

MeSH terms

  • Arginine / antagonists & inhibitors*
  • Lysine / pharmacology*
  • Simplexvirus / drug effects*
  • Virus Cultivation
  • Virus Replication / drug effects


  • Arginine
  • Lysine