Gastric emptying rate in the elderly: implications for drug therapy

J Am Geriatr Soc. 1981 May;29(5):201-5. doi: 10.1111/j.1532-5415.1981.tb01766.x.

Abstract

The effect of the aging process on gastric emptying was studied in 11 elderly subjects (mean age, 77) and in 7 young healthy volunteers (mean age, 26). Gastric emptying rates were assessed by a modified sequential scinti-scanning technique after administration of the nonabsorbable chelated radiopharmaceutical 99mTc-DTPA. The rate of emptying, expressed as half-time (T 1/2e) in minutes, was significantly longer (p less than 0.001) in the elderly subjects (mean apparent T 1/2e = 123.23 min) compared to the young healthy volunteers (mean apparent T 1/2e = 49.69 min). Clinical implications of these findings are discussed, particularly with respect to the rate and extent of drug absorption in elderly persons.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • Aging*
  • Female
  • Gastric Emptying*
  • Humans
  • Male
  • Pentetic Acid
  • Sodium Pertechnetate Tc 99m
  • Technetium
  • Technetium Tc 99m Pentetate
  • Time Factors

Substances

  • Technetium
  • Pentetic Acid
  • Sodium Pertechnetate Tc 99m
  • Technetium Tc 99m Pentetate